SPTBN1

Across TCGA cell cohorts, SPTBN1 mutation is significantly associated with the mutation status of many other genes, with 5,869 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPTBN1-associated genes across cancer lineages are KDM5A, SPEN, and UBE4B. Each is linked with SPTBN1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SPTBN1-to-partner and partner-to-SPTBN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KDM5A grouped by SPTBN1-low versus SPTBN1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN1→partner) and Y-score (partner→SPTBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KDM5A →	+3.554	+3.731	.003	.003	1	7
PANCREAS	SPEN →	+3.321	+3.614	.006	.006	1	6
BLOOD_Lymphoma	UBE4B →	+2.969	+3.337	.009	.009	1	6
OVARY	TLN1 →	+4.196	+2.632	.002	.002	1	6
BREAST	SACS →	+4.807	+3.857	.002	.002	1	6
BLOOD_Lymphoma	TNXB →	+2.269	+3.287	.007	.007	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,869 associations by consensus.

KDM5A by SPTBN1 expression — BLOOD_Lymphoma

Explore this box plot interactively →