Across TCGA patient cohorts, SPTAN1 mutation is significantly associated with the RNA expression of many other genes, with 6,642 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTAN1-associated genes across cancer lineages are DCLRE1A, BAK1, and NANS. Each is linked with SPTAN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPTAN1-to-partner and partner-to-SPTAN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTAN1→partner) and Y-score (partner→SPTAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	DCLRE1A →	+0.717	+3.459	<.001	.005	3	4
COAD	BAK1 →	+0.489	+2.638	<.001	<.001	3	4
UCEC	NANS →	+0.392	+1.425	<.001	<.001	3	4
UCEC	BCL2L2-PABPN1 →	+0.169	+1.059	<.001	.009	3	4
COAD	MCM5 →	+0.647	+3.288	<.001	<.001	3	4
COAD	XPNPEP1 →	+0.390	+2.087	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,642 associations by consensus.

Exploration

SPTAN1 survival (RNA) · tumor vs normal (RNA) · all SPTAN1 data types