SPSB3

Across TCGA pan-cancer cohorts, SPSB3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPSB3 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SPSB3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPSB3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, BLCA, and LUAD are the cancer types where SPSB3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	II,III,IV	0.029	0.691	<.001	24	view →
BLCA	DFS	Median	All	0.127	0.627	<.001	12	view →
LUAD	OS	Median	All	0.322	0.685	.024	6	view →
UCEC	DFS	Median	All	1.000	0.637	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPSB3–SKCM (DFS)

Open the SKCM breakdown →