SPSB3

Across TCGA patient cohorts, SPSB3 protein abundance is significantly associated with the RNA expression of many other genes, with 250 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SPSB3-associated genes across cancer lineages are MIR491, RABAC1, and FTH1P7. Each is linked with SPSB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPSB3-to-partner and partner-to-SPSB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPSB3 versus MIR491 in LSCC, with a Pearson correlation of -0.84.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPSB3→partner) and Y-score (partner→SPSB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MIR491 →	-0.987	-0.897	.002	.009	3	2
GBM	RABAC1 →	-0.668	-0.384	.009	.005	3	1
GBM	FTH1P7 →	+0.759	+0.523	.003	.005	3	1
GBM	RN7SL521P →	-1.066	-0.516	.001	.007	3	1
GBM	LMNTD2-AS1 →	+0.450	+0.523	.007	.005	3	1
GBM	PHBP19 →	-1.493	-0.523	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 250 associations by consensus.

SPSB3 vs MIR491 — LSCC

Explore this scatter interactively →