SPSB3

Across TCGA patient cohorts, SPSB3 mutation is significantly associated with the RNA expression of many other genes, with 673 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPSB3-associated genes across cancer lineages are RNU7-197P, RNA5SP369, and RNU6ATAC30P. Each is linked with SPSB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPSB3-to-partner and partner-to-SPSB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-197P grouped by SPSB3-low versus SPSB3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPSB3→partner) and Y-score (partner→SPSB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU7-197P →	+0.558	+7.930	<.001	.008	3	3
UCEC	RNA5SP369 →	+0.272	+2.193	.009	.005	3	3
COAD	RNU6ATAC30P →	+0.812	+4.308	<.001	.009	3	2
COAD	RNU6ATAC25P →	+0.570	+5.332	<.001	.002	3	2
COAD	RNU2-61P →	+1.446	+4.666	<.001	.005	3	2
STAD	RN7SKP257 →	+0.146	+3.350	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 673 associations by consensus.

RNU7-197P by SPSB3 expression — LUAD

Explore this box plot interactively →