SPSB3

Across TCGA patient cohorts, SPSB3 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPSB3-associated genes across cancer lineages are eIF4E, IRS1, and p27_pT157. Each is linked with SPSB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPSB3-to-partner and partner-to-SPSB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SPSB3-low versus SPSB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPSB3→partner) and Y-score (partner→SPSB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.241	+3.183	.008	.009	3	1
UCEC	IRS1 →	-0.304	-3.459	<.001	.005	3	1
UCEC	p27_pT157 →	-0.071	-3.308	.005	.009	3	1
UCEC	p62 Lck ligand →	+0.433	+2.469	.002	.010	3	1
UCEC	Akt_pT308 →	+0.604	+2.999	.028	.035	3	1
UCEC	Annexin-1 →	+0.785	+2.479	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4E by SPSB3 expression — UCEC

Explore this box plot interactively →