SPSB3

Across TCGA cell cohorts, SPSB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,060 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPSB3-associated GO terms across cancer lineages are Flagellated sperm motility, Sperm motility, and Cilium or flagellum-dependent cell motility. Each is linked with SPSB3 in more than 17 cancer types. Because this analysis shows association rather than direction, both SPSB3-to-partner and partner-to-SPSB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Flagellated sperm motility grouped by SPSB3-low versus SPSB3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPSB3→partner) and Y-score (partner→SPSB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.130	-0.795	<.001	.005	3	18
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.130	-0.795	<.001	.005	3	18
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.129	-0.848	<.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.129	-0.848	<.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.131	-0.764	<.001	.002	3	17
UPPER_AERODIGESTIVE_TRACT	Positive regulation of autophagy →	+0.076	+1.146	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,060 associations by consensus.

Flagellated sperm motility by SPSB3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →