SPSB3

Across TCGA cell cohorts, SPSB3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPSB3-associated genes across cancer lineages are CLDN34, FAM205A, and PADI6. Each is linked with SPSB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPSB3-to-partner and partner-to-SPSB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN34 grouped by SPSB3-low versus SPSB3-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPSB3→partner) and Y-score (partner→SPSB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CLDN34 →	+0.043	+4.807	<.001	.006	3	1
LARGE_INTESTINE	FAM205A →	+0.018	+3.614	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	PADI6 →	+0.038	+4.510	<.001	.003	3	1
BLOOD_Leukemia	SLITRK3 →	+0.029	+3.289	<.001	.009	3	1
BLOOD_Leukemia	HMX1 →	+0.301	+3.234	.009	.008	3	1
BLOOD_Leukemia	LGI3 →	+0.122	+3.491	.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CLDN34 by SPSB3 expression — BLOOD_Myeloma

Explore this box plot interactively →