SPSB1

Across TCGA patient cohorts, SPSB1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPSB1-associated genes across cancer lineages are GATA6, NF2, and P-Cadherin. Each is linked with SPSB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPSB1-to-partner and partner-to-SPSB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by SPSB1-low versus SPSB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPSB1→partner) and Y-score (partner→SPSB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.167	-2.577	.020	.011	3	1
UCEC	NF2 →	+0.290	+2.584	.004	.011	3	1
UCEC	P-Cadherin →	-0.200	-3.159	.002	.019	3	1
UCEC	Shc_pY317 →	-0.210	-2.584	.003	.011	3	1
UCEC	4E-BP1 →	+0.281	+3.029	.026	.018	3	1
UCEC	C-Raf →	+0.244	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GATA6 by SPSB1 expression — UCEC

Explore this box plot interactively →