SPRYD7

Across TCGA patient cohorts, SPRYD7 mutation is significantly associated with the RNA expression of many other genes, with 451 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRYD7-associated genes across cancer lineages are CFL1P8, RNA5SP335, and MIR188. Each is linked with SPRYD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRYD7-to-partner and partner-to-SPRYD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFL1P8 grouped by SPRYD7-low versus SPRYD7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRYD7→partner) and Y-score (partner→SPRYD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CFL1P8 →	+0.146	+4.500	<.001	.005	3	2
LUSC	RNA5SP335 →	+0.290	+5.191	<.001	.003	3	2
LUSC	MIR188 →	+0.245	+5.733	<.001	.001	3	2
LUSC	MIR3129 →	+0.998	+4.503	<.001	.005	3	2
LUSC	RAB28P4 →	+0.195	+6.327	<.001	<.001	3	2
LUAD	RNA5SP484 →	+0.336	+5.888	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 451 associations by consensus.

CFL1P8 by SPRYD7 expression — SKCM

Explore this box plot interactively →