SPRYD3

Across TCGA patient cohorts, SPRYD3 mutation is significantly associated with the RNA expression of many other genes, with 571 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRYD3-associated genes across cancer lineages are MIR6766, NDUFAF2, and KARS1. Each is linked with SPRYD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRYD3-to-partner and partner-to-SPRYD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6766 grouped by SPRYD3-low versus SPRYD3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRYD3→partner) and Y-score (partner→SPRYD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR6766 →	+0.721	+5.018	<.001	.004	3	2
UCEC	NDUFAF2 →	+0.687	+3.332	.001	.005	3	2
UCEC	KARS1 →	+0.522	+3.483	.001	.002	3	2
UCEC	RNF103-CHMP3 →	+0.256	+2.595	<.001	.006	3	2
SKCM	MRPL35P4 →	+0.036	+2.596	.001	.008	3	2
BLCA	EEF1A1P41 →	+0.221	+4.299	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 571 associations by consensus.

MIR6766 by SPRYD3 expression — BLCA

Explore this box plot interactively →