SPRYD3

Across TCGA cell cohorts, SPRYD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,431 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SPRYD3-associated GO terms across cancer lineages are Positive regulation of autophagy, Endosomal transport, and Cytosolic transport. Each is linked with SPRYD3 in more than 11 cancer types. Because this analysis shows association rather than direction, both SPRYD3-to-partner and partner-to-SPRYD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of autophagy grouped by SPRYD3-low versus SPRYD3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRYD3→partner) and Y-score (partner→SPRYD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of autophagy →	+0.059	+0.819	<.001	.001	3	11
BREAST	Endosomal transport →	+0.055	+0.765	<.001	.003	2	12
BONE	Cytosolic transport →	+0.073	+0.726	<.001	<.001	3	11
BONE	Membrane protein ectodomain proteolysis →	+0.124	+0.626	.003	.004	3	11
BONE	Phosphatidylinositol biosynthetic process →	+0.059	+0.814	<.001	<.001	3	11
SOFT_TISSUE	Vesicle cytoskeletal trafficking →	+0.051	+0.925	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,431 associations by consensus.

Positive regulation of autophagy by SPRYD3 expression — PANCREAS

Explore this box plot interactively →