SPRYD3

Across TCGA cell cohorts, SPRYD3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPRYD3-associated genes across cancer lineages are CST5, MROH2B, and OR13G1. Each is linked with SPRYD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRYD3-to-partner and partner-to-SPRYD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST5 grouped by SPRYD3-low versus SPRYD3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRYD3→partner) and Y-score (partner→SPRYD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CST5 →	+0.532	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MROH2B →	+0.116	+5.643	<.001	.002	3	1
LARGE_INTESTINE	OR13G1 →	+0.024	+4.415	<.001	.007	3	1
SKIN	KRTAP13-4 →	+0.030	+5.022	<.001	.002	3	1
SKIN	ARMH2 →	+0.011	+4.415	<.001	.007	3	1
BLOOD_Leukemia	MYOD1 →	+0.022	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CST5 by SPRYD3 expression — BLOOD_Lymphoma

Explore this box plot interactively →