Across TCGA patient cohorts, SPRY4 RNA expression is significantly associated with the RNA expression of many other genes, with 19,446 significant associations in total. THYM shows the largest number of these associations.

The most reproducible SPRY4-associated genes across cancer lineages are SPRY2, SPRED1, and SPRED2. Each is linked with SPRY4 in more than 33 cancer types. Because this analysis shows association rather than direction, both SPRY4-to-partner and partner-to-SPRY4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY4→partner) and Y-score (partner→SPRY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	SPRY2 →	+1.855	+1.819	<.001	<.001	3	34
THYM	SPRED1 →	+1.494	+1.521	<.001	<.001	3	33
LGG	SPRED2 →	+1.524	+2.435	<.001	<.001	3	32
KICH	AFF4 →	+1.335	+1.229	<.001	<.001	3	32
THYM	EFNB2 →	+1.669	+1.470	<.001	<.001	3	32
KIRP	DUSP6 →	+1.954	+1.657	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,446 associations by consensus.

Exploration

SPRY4 survival (RNA) · tumor vs normal (RNA) · all SPRY4 data types