Across TCGA patient cohorts, SPRY4 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,721 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPRY4-associated proteins across cancer lineages are SPRY4_S280, TLN1_Y70, and PIK3C2A_S259. Each is linked with SPRY4 in more than 6 cancer types. Because this analysis shows association rather than direction, both SPRY4-to-partner and partner-to-SPRY4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY4→partner) and Y-score (partner→SPRY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPRY4_S280 →	+1.197	+1.005	<.001	<.001	3	7
PDAC	TLN1_Y70 →	+0.973	+0.689	<.001	<.001	3	7
UCEC	PIK3C2A_S259 →	+0.547	+1.044	<.001	<.001	3	6
OV	SEPTIN4 →	+0.444	+0.852	<.001	.002	3	5
LUAD	SPRY4_S125 →	+0.548	+0.989	<.001	<.001	3	5
OV	ILK →	+0.416	+1.448	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,721 associations by consensus.

Exploration

SPRY4 survival (RNA) · tumor vs normal (RNA) · all SPRY4 data types