Across TCGA patient cohorts, SPRY4 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRY4-associated genes across cancer lineages are Akt_pT308, EGFR_pY1068, and GSK-3a-b_pS21_S9. Each is linked with SPRY4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRY4-to-partner and partner-to-SPRY4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY4→partner) and Y-score (partner→SPRY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.741	+3.169	.011	.018	3	2
UCEC	EGFR_pY1068 →	-0.239	-2.584	.040	.011	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.503	+2.584	.011	.011	3	1
UCEC	Myosin-IIa_pS1943 →	+0.284	+3.169	.003	.018	3	1
UCEC	Myosin-IIa →	+0.226	+1.881	.008	.031	3	1
UCEC	p62 Lck ligand →	+0.386	+3.700	.010	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

SPRY4 survival (RNA) · tumor vs normal (RNA) · all SPRY4 data types