SPRY4

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, SPRY4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,751 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SPRY4-associated GO terms across cancer lineages are Negative regulation of lens fiber cell differentiation, Regulation of lens fiber cell differentiation, and Negative regulation of fibroblast growth factor receptor signaling pathway. Each is linked with SPRY4 in more than 13 cancer types. Because this analysis shows association rather than direction, both SPRY4-to-partner and partner-to-SPRY4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY4→partner) and Y-score (partner→SPRY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UPPER_AERODIGESTIVE_TRACTNegative regulation of lens fiber cell differentiation →+1.149+1.826<.001<.001313
UPPER_AERODIGESTIVE_TRACTRegulation of lens fiber cell differentiation →+1.150+1.492<.001.001214
LUNG_SCLCNegative regulation of fibroblast growth factor receptor signaling pathway →+0.871+2.109<.001<.001312
BREASTNegative regulation of epidermal growth factor receptor signaling pathway →+0.091+2.048<.001<.001210
LUNG_NSCLC_LUADNegative regulation of ERBB signaling pathway →+0.094+1.655<.001<.00139
STOMACHNegative regulation of Ras protein signal transduction →+0.113+1.559<.001.00339
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,751 associations by consensus.

Exploration