SPRY3

Across TCGA pan-cancer cohorts, SPRY3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPRY3 data layer compared with 24 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SPRY3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPRY3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, GBM, and LUAD are the cancer types where SPRY3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.337	.008	32	view →
GBM	OS	Median	All	0.573	0.975	<.001	7	view →
LUAD	DFS	Median	II,III,IV	0.315	0.970	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPRY3–UCEC (DFS)

Open the UCEC breakdown →