SPRY3

Across TCGA patient cohorts, SPRY3 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,326 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPRY3-associated proteins across cancer lineages are DDX21_S89, NFIB, and TMLHE. Each is linked with SPRY3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPRY3-to-partner and partner-to-SPRY3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPRY3 versus DDX21_S89 in OV, with a Pearson correlation of -0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY3→partner) and Y-score (partner→SPRY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DDX21_S89 →	-0.824	-0.524	.003	.003	3	5
BRCA	NFIB →	+0.533	+0.377	.003	.004	3	5
UCEC	TMLHE →	+0.492	+0.801	.003	.003	2	5
BRCA	PGRMC1 →	+0.456	+0.437	.006	.001	3	4
HNSC	RPL5 →	-0.172	-0.427	<.001	<.001	3	4
LUAD	CEBPZ_S629 →	-0.389	-0.402	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,326 associations by consensus.

SPRY3 vs DDX21_S89 — OV

Explore this scatter interactively →