SPRY3

Across TCGA patient cohorts, SPRY3 protein abundance is significantly associated with the RNA expression of many other genes, with 616 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRY3-associated genes across cancer lineages are PIP5K1B, GAPLINC, and SIX4. Each is linked with SPRY3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRY3-to-partner and partner-to-SPRY3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPRY3 versus PIP5K1B in GBM, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY3→partner) and Y-score (partner→SPRY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIP5K1B →	+0.886	+0.901	<.001	<.001	3	2
UCEC	GAPLINC →	-0.833	-1.121	.001	<.001	3	2
UCEC	SIX4 →	+0.866	+1.140	.003	.001	3	1
UCEC	SYNDIG1 →	-1.115	-0.871	<.001	.003	3	1
UCEC	PRKD2 →	+0.504	+1.144	.004	.003	3	1
UCEC	MYH14 →	+1.155	+0.883	.002	.007	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 616 associations by consensus.

SPRY3 vs PIP5K1B — GBM

Explore this scatter interactively →