SPRY3

Across TCGA patient cohorts, SPRY3 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRY3-associated genes across cancer lineages are GAPDH, NF2, and p62 Lck ligand. Each is linked with SPRY3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPRY3-to-partner and partner-to-SPRY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by SPRY3-low versus SPRY3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY3→partner) and Y-score (partner→SPRY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.498	+2.423	.006	.001	3	3
UCEC	NF2 →	+0.276	+2.700	<.001	.005	3	3
COAD	p62 Lck ligand →	+0.288	+1.493	.040	.035	3	3
COAD	EGFR_pY1068 →	-0.350	-2.102	.003	.017	3	2
UCEC	eIF4E →	+0.167	+2.183	.024	.033	3	2
UCEC	JNK2 →	+0.361	+3.523	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

GAPDH by SPRY3 expression — COAD

Explore this box plot interactively →