SPRY3

Across TCGA cell cohorts, SPRY3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,349 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SPRY3-associated GO terms across cancer lineages are Macroautophagy, Regulation of protein localization to nucleus, and Process utilizing autophagic mechanism. Each is linked with SPRY3 in more than 12 cancer types. Because this analysis shows association rather than direction, both SPRY3-to-partner and partner-to-SPRY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macroautophagy grouped by SPRY3-low versus SPRY3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY3→partner) and Y-score (partner→SPRY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.061	+0.313	.001	.001	3	13
PANCREAS	Regulation of protein localization to nucleus →	+0.063	+0.277	.004	.003	3	13
UPPER_AERODIGESTIVE_TRACT	Process utilizing autophagic mechanism →	+0.040	+0.275	.003	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Autophagy →	+0.040	+0.275	.003	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.062	+0.304	<.001	<.001	3	12
OESOPHAGUS	Regulation of macroautophagy →	+0.070	+0.360	<.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,349 associations by consensus.

Macroautophagy by SPRY3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →