SPRY3

Across TCGA cell cohorts, SPRY3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPRY3-associated genes across cancer lineages are CCDC182, PRAMEF15, and UBQLN3. Each is linked with SPRY3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRY3-to-partner and partner-to-SPRY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC182 grouped by SPRY3-low versus SPRY3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY3→partner) and Y-score (partner→SPRY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CCDC182 →	+0.031	+4.981	<.001	.008	3	1
CNS	PRAMEF15 →	+0.345	+4.981	<.001	.008	3	1
SKIN	UBQLN3 →	+0.012	+4.415	<.001	.007	3	1
SKIN	REC114 →	+0.136	+4.095	<.001	.009	3	1
SKIN	OPN1MW →	+0.027	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TBX22 →	+0.027	+4.047	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

CCDC182 by SPRY3 expression — CNS

Explore this box plot interactively →