SPRY2

Across TCGA patient cohorts, SPRY2 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,324 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SPRY2-associated proteins across cancer lineages are SPRY2_S139, TRIM2, and CD38. Each is linked with SPRY2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPRY2-to-partner and partner-to-SPRY2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPRY2 versus SPRY2_S139 in OV, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY2→partner) and Y-score (partner→SPRY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPRY2_S139 →	+1.213	+1.326	<.001	<.001	3	5
HNSC	TRIM2 →	+0.778	+0.949	<.001	<.001	3	5
LSCC	CD38 →	-0.741	-1.011	<.001	<.001	3	5
BRCA	CPNE2 →	+0.315	+0.877	<.001	<.001	3	5
LSCC	EVI2B_S268 →	-0.825	-0.822	.002	.003	3	5
PDAC	FMNL1 →	-0.469	-0.794	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,324 associations by consensus.

SPRY2 vs SPRY2_S139 — OV

Explore this scatter interactively →