SPRY2

Across TCGA patient cohorts, SPRY2 protein abundance is significantly associated with the RNA expression of many other genes, with 3,646 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPRY2-associated genes across cancer lineages are ANKRD18B, ALDH1L2, and LRP12. Each is linked with SPRY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRY2-to-partner and partner-to-SPRY2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPRY2 versus ANKRD18B in UCEC, with a Pearson correlation of 0.81.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY2→partner) and Y-score (partner→SPRY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANKRD18B →	+0.956	+1.915	.001	.002	3	2
HNSC	ALDH1L2 →	+1.491	+1.061	<.001	<.001	3	2
HNSC	LRP12 →	+1.415	+1.097	.006	.005	3	2
HNSC	DEFA4 →	-0.430	-1.158	.006	.002	3	2
HNSC	PSAP →	-1.410	-1.205	.002	.002	3	2
HNSC	LINC02648 →	-0.929	-1.031	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,646 associations by consensus.

SPRY2 vs ANKRD18B — UCEC

Explore this scatter interactively →