SPRY2

Across TCGA patient cohorts, SPRY2 mutation is significantly associated with the RNA expression of many other genes, with 1,606 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRY2-associated genes across cancer lineages are MIR6853, HSD17B12, and FADS1. Each is linked with SPRY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRY2-to-partner and partner-to-SPRY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6853 grouped by SPRY2-low versus SPRY2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY2→partner) and Y-score (partner→SPRY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6853 →	+0.181	+7.473	<.001	.007	3	1
UCEC	HSD17B12 →	+0.648	+4.169	<.001	<.001	3	1
UCEC	FADS1 →	+0.611	+3.087	.009	<.001	3	1
UCEC	MRPL49 →	+0.514	+3.119	.003	<.001	3	1
UCEC	TIRAP →	+0.494	+3.609	.002	.001	3	1
UCEC	DLAT →	+0.655	+3.087	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,606 associations by consensus.

MIR6853 by SPRY2 expression — BRCA

Explore this box plot interactively →