SPRY2

Across TCGA patient cohorts, SPRY2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRY2-associated genes across cancer lineages are C-Raf, ACC1, and Ku80. Each is linked with SPRY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRY2-to-partner and partner-to-SPRY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by SPRY2-low versus SPRY2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY2→partner) and Y-score (partner→SPRY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.199	+2.222	.001	.011	3	2
UCEC	ACC1 →	+0.392	+1.700	.010	.044	3	1
UCEC	Ku80 →	+0.275	+2.009	.005	.017	3	1
UCEC	MSH6 →	-0.320	-2.999	.022	.035	3	1
UCEC	Notch1 →	+0.174	+2.331	.003	.019	3	1
UCEC	p62 Lck ligand →	+0.281	+2.179	.042	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

C-Raf by SPRY2 expression — UCEC

Explore this box plot interactively →