SPRY2

Across TCGA cell cohorts, SPRY2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,095 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPRY2-associated GO terms across cancer lineages are Negative regulation of lens fiber cell differentiation, Regulation of lens fiber cell differentiation, and Positive regulation of peptidyl-serine phosphorylation. Each is linked with SPRY2 in more than 15 cancer types. Because this analysis shows association rather than direction, both SPRY2-to-partner and partner-to-SPRY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of lens fiber cell differentiation grouped by SPRY2-low versus SPRY2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY2→partner) and Y-score (partner→SPRY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of lens fiber cell differentiation →	+1.241	+1.737	<.001	.002	3	16
BLOOD_Myeloma	Regulation of lens fiber cell differentiation →	+0.988	+1.082	<.001	.009	3	15
URINARY_TRACT	Positive regulation of peptidyl-serine phosphorylation →	+0.122	+1.780	<.001	<.001	3	13
BREAST	Regulation of peptidyl-serine phosphorylation →	+0.112	+2.089	<.001	<.001	3	12
SKIN	Negative regulation of small GTPase mediated signal transduction →	+0.078	+1.934	<.001	.001	3	11
LUNG_NSCLC_LUSC	Negative regulation of Ras protein signal transduction →	+0.181	+2.774	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,095 associations by consensus.

Negative regulation of lens fiber cell differentiation by SPRY2 expression — LUNG_SCLC

Explore this box plot interactively →