SPRY2

Across TCGA cell cohorts, SPRY2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible SPRY2-associated genes across cancer lineages are IFIT1B, MRAP, and USP17L15. Each is linked with SPRY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRY2-to-partner and partner-to-SPRY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFIT1B grouped by SPRY2-low versus SPRY2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY2→partner) and Y-score (partner→SPRY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	IFIT1B →	+0.013	+4.807	<.001	.006	3	2
BLOOD_Myeloma	MRAP →	+0.073	+4.807	<.001	.006	3	1
BLOOD_Myeloma	USP17L15 →	+0.013	+4.807	<.001	.006	3	1
SOFT_TISSUE	H2BW2 →	+0.049	+4.930	<.001	.008	3	1
SOFT_TISSUE	C20orf173 →	+0.025	+4.930	<.001	.008	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

IFIT1B by SPRY2 expression — BLOOD_Myeloma

Explore this box plot interactively →