SPRR3

Across TCGA pan-cancer cohorts, SPRR3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPRR3 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SPRR3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPRR3 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

OV, LUSC, and SKCM are the cancer types where SPRR3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	II,III,IV	0.193	0.541	.013	18	view →
LUSC	DFS	Median	All	0.135	0.760	<.001	12	view →
SKCM	OS	Median	II,III,IV	0.948	0.719	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPRR3–OV (DFS)

Open the OV breakdown →