SPRR3

Across TCGA pan-cancer cohorts, SPRR3 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SPRR3 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SPRR3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPRR3 expression acts as an unfavorable survival marker.

PDAC are the cancer types where SPRR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.557	0.889	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

SPRR3–PDAC (DFS)

Open the PDAC breakdown →