SPRR3

Across TCGA patient cohorts, SPRR3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPRR3-associated genes across cancer lineages are Rictor, E-Cadherin, and RBM15. Each is linked with SPRR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR3-to-partner and partner-to-SPRR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor grouped by SPRR3-low versus SPRR3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR3→partner) and Y-score (partner→SPRR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rictor →	-0.367	-3.169	.036	.019	2	1
SKCM	E-Cadherin →	-1.332	-3.000	.005	.035	2	1
UCEC	RBM15 →	+0.385	+2.820	.048	.036	1	1
SKCM	ERCC1 →	+0.182	+3.186	.041	.010	1	1
SKCM	Acetyl-a-Tubulin-Lys40 →	-0.740	-3.169	.013	.019	1	1
SKCM	Chk1 →	+0.422	+3.204	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Rictor by SPRR3 expression — SKCM

Explore this box plot interactively →