SPRR3

Across TCGA cell cohorts, SPRR3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,728 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible SPRR3-associated GO terms across cancer lineages are Action potential propagation, NMDA selective glutamate receptor signaling pathway, and Response to indole-3-methanol. Each is linked with SPRR3 in more than 6 cancer types. Because this analysis shows association rather than direction, both SPRR3-to-partner and partner-to-SPRR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Action potential propagation grouped by SPRR3-low versus SPRR3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR3→partner) and Y-score (partner→SPRR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Action potential propagation →	-0.916	-2.594	<.001	<.001	3	7
URINARY_TRACT	NMDA selective glutamate receptor signaling pathway →	+0.282	+3.315	<.001	<.001	3	7
URINARY_TRACT	Response to indole-3-methanol →	+0.255	+3.664	<.001	<.001	3	6
STOMACH	Cellular response to indole-3-methanol →	+0.237	+2.287	<.001	.002	3	6
PANCREAS	AV node cell action potential →	+1.066	+1.788	<.001	<.001	3	6
PANCREAS	AV node cell to bundle of His cell signaling →	+1.066	+1.788	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,728 associations by consensus.

Action potential propagation by SPRR3 expression — URINARY_TRACT

Explore this box plot interactively →