SPRR2F

Across TCGA pan-cancer cohorts, SPRR2F Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SPRR2F data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SPRR2F Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPRR2F expression acts as an unfavorable survival marker.

CESC and BRCA are the cancer types where SPRR2F Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.176	0.740	.005	12	view →
BRCA	DFS	Median	All	0.112	0.526	.005	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SPRR2F–CESC (DFS)

Open the CESC breakdown →