SPRR2F

Across TCGA pan-cancer cohorts, SPRR2F mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPRR2F data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SPRR2F mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPRR2F expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where SPRR2F mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.971	0.715	.020	10	view →
LUAD	DFS	Median	All	0.675	1.000	.014	10	view →
HNSC	DFS	Median	IV	1.000	0.413	.033	7	view →
LSCC	OS	Tertile	All	1.000	0.938	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPRR2F–UCEC (DFS)

Open the UCEC breakdown →