Across TCGA patient cohorts, SPRR2E RNA expression is significantly associated with the go_rna of many other GO terms, with 6,765 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPRR2E-associated GO terms across cancer lineages are Desmosome organization, Keratinization, and Autocrine signaling. Each is linked with SPRR2E in more than 10 cancer types. Because this analysis shows association rather than direction, both SPRR2E-to-partner and partner-to-SPRR2E results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2E→partner) and Y-score (partner→SPRR2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	Desmosome organization →	+0.082	+1.816	<.001	<.001	2	11
ESCA	Keratinization →	+0.278	+6.671	<.001	<.001	3	10
ESCA	Autocrine signaling →	+0.164	+5.343	<.001	<.001	3	10
SKCM	Intermediate filament bundle assembly →	+0.234	+2.305	<.001	<.001	3	10
ESCA	Ammonium homeostasis →	+0.589	+6.253	<.001	<.001	3	9
STAD	Protein nitrosylation →	+0.038	+0.708	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,765 associations by consensus.

Exploration

SPRR2E survival (RNA) · tumor vs normal (RNA) · all SPRR2E data types