Across TCGA patient cohorts, SPRR2E mutation is significantly associated with the RNA expression of many other genes, with 192 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPRR2E-associated genes across cancer lineages are RNA5SP204, RNA5SP473, and MIR324. Each is linked with SPRR2E in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR2E-to-partner and partner-to-SPRR2E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2E→partner) and Y-score (partner→SPRR2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP204 →	+0.191	+7.930	<.001	.008	3	2
UCEC	RNA5SP473 →	+1.184	+3.481	<.001	<.001	3	2
SKCM	MIR324 →	+0.657	+3.840	<.001	.001	3	2
SKCM	MIR615 →	+0.236	+2.221	.008	.009	3	2
SKCM	HNRNPUL2-BSCL2 →	+0.326	+3.478	.002	.002	3	1
SKCM	SDHCP3 →	+0.137	+3.580	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 192 associations by consensus.

Exploration

SPRR2E survival (RNA) · tumor vs normal (RNA) · all SPRR2E data types