Across TCGA patient cohorts, SPRR2E mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRR2E-associated genes across cancer lineages are IGFBP2, Shc_pY317, and STAT3_pY705. Each is linked with SPRR2E in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR2E-to-partner and partner-to-SPRR2E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2E→partner) and Y-score (partner→SPRR2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-1.128	-3.000	.002	.037	3	1
UCEC	Shc_pY317 →	-0.273	-3.000	.001	.037	3	1
UCEC	STAT3_pY705 →	-0.314	-3.000	.038	.037	3	1
UCEC	Tuberin →	+0.384	+2.817	.013	.036	3	1
UCEC	Caspase-8 →	-0.338	-3.000	.020	.037	3	1
UCEC	Di-Ras3 →	-0.168	-3.000	.049	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

SPRR2E survival (RNA) · tumor vs normal (RNA) · all SPRR2E data types