Across TCGA cell cohorts, SPRR2E RNA expression is significantly associated with the go_rna of many other GO terms, with 730 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SPRR2E-associated GO terms across cancer lineages are NMDA selective glutamate receptor signaling pathway, Axoneme assembly, and Negative regulation of viral genome replication. Each is linked with SPRR2E in more than 5 cancer types. Because this analysis shows association rather than direction, both SPRR2E-to-partner and partner-to-SPRR2E results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2E→partner) and Y-score (partner→SPRR2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NMDA selective glutamate receptor signaling pathway →	+0.223	+1.884	.009	.007	3	6
LARGE_INTESTINE	Axoneme assembly →	-0.033	-0.398	.001	.007	3	6
LUNG_NSCLC_LUAD	Negative regulation of viral genome replication →	+0.075	+0.147	.003	.008	3	5
SOFT_TISSUE	Regulation of positive chemotaxis →	+0.270	+0.033	<.001	.008	3	5
SOFT_TISSUE	Positive regulation of positive chemotaxis →	+0.285	+0.033	<.001	.008	3	5
LARGE_INTESTINE	Mammary gland morphogenesis →	+0.134	+0.392	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 730 associations by consensus.

Exploration

SPRR2E survival (RNA) · tumor vs normal (RNA) · all SPRR2E data types