SPRR2D

Across TCGA pan-cancer cohorts, SPRR2D mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPRR2D data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPRR2D mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SPRR2D expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where SPRR2D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.925	0.758	.006	68	view →
LUAD	DFS	Median	All	0.361	1.000	.007	4	view →
UCEC	OS	Tertile	All	1.000	0.814	.024	2	view →
PDAC	DFS	Median	All	0.743	0.863	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPRR2D–HNSC (OS)

Open the HNSC breakdown →