SPRR2D

Across TCGA patient cohorts, SPRR2D mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRR2D-associated genes across cancer lineages are MEK1, Stathmin, and PCNA. Each is linked with SPRR2D in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR2D-to-partner and partner-to-SPRR2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SPRR2D-low versus SPRR2D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2D→partner) and Y-score (partner→SPRR2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.460	+3.000	.029	.036	3	1
UCEC	Stathmin →	+0.254	+3.000	.001	.037	3	1
UCEC	PCNA →	+0.261	+3.000	.037	.037	2	1
UCEC	SLC1A5 →	-0.501	-2.992	.041	.036	1	1
UCEC	VHL →	-1.003	-3.000	.010	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEK1 by SPRR2D expression — UCEC

Explore this box plot interactively →