SPRR1B

Across TCGA pan-cancer cohorts, SPRR1B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPRR1B data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPRR1B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SPRR1B expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where SPRR1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.912	0.783	.014	20	view →
PDAC	OS	Quartile	II,III,IV	0.341	0.605	.017	9	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.819	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPRR1B–HNSC (OS)

Open the HNSC breakdown →