SPRR1B

Across TCGA cell cohorts, SPRR1B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,279 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible SPRR1B-associated GO terms across cancer lineages are NMDA selective glutamate receptor signaling pathway, Cell-substrate junction organization, and Maintenance of blood-brain barrier. Each is linked with SPRR1B in more than 7 cancer types. Because this analysis shows association rather than direction, both SPRR1B-to-partner and partner-to-SPRR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NMDA selective glutamate receptor signaling pathway grouped by SPRR1B-low versus SPRR1B-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR1B→partner) and Y-score (partner→SPRR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NMDA selective glutamate receptor signaling pathway →	+0.260	+3.346	<.001	.002	3	8
PANCREAS	Cell-substrate junction organization →	+0.188	+3.480	<.001	<.001	3	8
BREAST	Maintenance of blood-brain barrier →	+0.196	+1.897	<.001	.001	3	8
LARGE_INTESTINE	Protein targeting to membrane →	+0.041	+1.197	.006	.009	3	8
PANCREAS	Cell-substrate junction assembly →	+0.208	+3.869	<.001	<.001	3	8
STOMACH	Positive regulation of epidermis development →	+0.109	+1.342	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,279 associations by consensus.

NMDA selective glutamate receptor signaling pathway by SPRR1B expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →