SPRR1A

Across TCGA pan-cancer cohorts, SPRR1A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPRR1A data layer compared with 24 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SPRR1A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPRR1A expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where SPRR1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.854	0.307	.003	21	view →
HNSC	OS	Quartile	All	0.915	0.725	.023	11	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.867	.028	4	view →
PDAC	DFS	Median	III,IV	0.533	0.219	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPRR1A–LUAD (DFS)

Open the LUAD breakdown →