SPRR1A

Across TCGA pan-cancer cohorts, SPRR1A mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SPRR1A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SPRR1A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SPRR1A is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC, LSCC, and PDAC are the cancer types where SPRR1A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPRR1A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.453	<.001	8	view →
LSCC	Male	II,III,IV	+1.129	<.001	8	view →
PDAC	All	All	+0.566	.009	4	view →
LUAD	All	All	+0.562	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SPRR1A–HNSC

Open the HNSC breakdown →