SPRR1A

Across TCGA cell cohorts, SPRR1A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,782 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible SPRR1A-associated GO terms across cancer lineages are NMDA selective glutamate receptor signaling pathway, Response to indole-3-methanol, and Cell communication involved in cardiac conduction. Each is linked with SPRR1A in more than 6 cancer types. Because this analysis shows association rather than direction, both SPRR1A-to-partner and partner-to-SPRR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NMDA selective glutamate receptor signaling pathway grouped by SPRR1A-low versus SPRR1A-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR1A→partner) and Y-score (partner→SPRR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NMDA selective glutamate receptor signaling pathway →	+0.281	+3.116	<.001	.003	3	7
URINARY_TRACT	Response to indole-3-methanol →	+0.220	+2.365	<.001	<.001	3	7
URINARY_TRACT	Cell communication involved in cardiac conduction →	+0.245	+1.750	<.001	<.001	3	7
URINARY_TRACT	Bundle of His cell to Purkinje myocyte communication →	+0.405	+2.207	.006	<.001	3	7
URINARY_TRACT	Cellular response to alcohol →	+0.103	+2.446	<.001	<.001	3	7
URINARY_TRACT	Mammary gland development →	+0.131	+1.876	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,782 associations by consensus.

NMDA selective glutamate receptor signaling pathway by SPRR1A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →