SPRING1

Across TCGA pan-cancer cohorts, SPRING1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPRING1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SPRING1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPRING1 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

ACC, STAD, and UCEC are the cancer types where SPRING1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.099	0.674	<.001	36	view →
STAD	OS	Median	IV	1.000	0.299	.047	2	view →
UCEC	DFS	Median	All	1.000	0.624	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPRING1–ACC (DFS)

Open the ACC breakdown →