Across TCGA patient cohorts, SPRED2 protein abundance is significantly associated with the protein abundance of many other proteins, with 2,709 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPRED2-associated proteins across cancer lineages are SPRY4_S125, CYBB, and SPRED2_S206. Each is linked with SPRED2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRED2-to-partner and partner-to-SPRED2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED2→partner) and Y-score (partner→SPRED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPRY4_S125 →	+0.539	+0.463	<.001	<.001	3	2
BRCA	CYBB →	+1.137	+0.795	.001	.001	3	2
GBM	SPRED2_S206 →	+0.770	+0.359	<.001	<.001	3	1
GBM	SPRED3 →	+0.814	+0.423	<.001	<.001	3	1
GBM	SPRY1 →	+0.778	+0.398	<.001	<.001	3	1
GBM	SPRY1_S150 →	+1.618	+0.527	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,709 associations by consensus.

Exploration

SPRED2 survival (RNA) · tumor vs normal (RNA) · all SPRED2 data types