Across TCGA patient cohorts, SPRED2 mutation is significantly associated with the RNA expression of many other genes, with 2,581 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRED2-associated genes across cancer lineages are LHX6, AKR1A1, and TSPY26P. Each is linked with SPRED2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPRED2-to-partner and partner-to-SPRED2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED2→partner) and Y-score (partner→SPRED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LHX6 →	-0.286	-1.957	.007	.009	3	3
UCEC	AKR1A1 →	+0.271	+2.024	.006	.005	3	3
UCEC	TSPY26P →	-0.569	-1.777	.005	.002	3	3
UCEC	SFXN1 →	+0.423	+2.736	<.001	<.001	3	3
UCEC	GHITM →	+0.570	+2.717	<.001	<.001	3	3
UCEC	MRPL16 →	+0.256	+1.856	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,581 associations by consensus.

Exploration

SPRED2 survival (RNA) · tumor vs normal (RNA) · all SPRED2 data types