Across TCGA patient cohorts, SPRED2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRED2-associated genes across cancer lineages are GAPDH, mTOR_pS2448, and c-Met_pY1235. Each is linked with SPRED2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPRED2-to-partner and partner-to-SPRED2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED2→partner) and Y-score (partner→SPRED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.377	+1.440	.043	.024	3	3
UCEC	mTOR_pS2448 →	-0.115	-2.202	.025	.010	3	3
UCEC	c-Met_pY1235 →	+0.053	+1.736	.037	.007	3	3
SKCM	14-3-3_epsilon →	+0.182	+2.186	.003	.034	3	2
UCEC	EGFR_pY1068 →	-0.308	-2.938	<.001	<.001	3	2
UCEC	MEK1 →	+0.454	+2.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration

SPRED2 survival (RNA) · tumor vs normal (RNA) · all SPRED2 data types